反应 #1470438

反应方程式

thionyl chloride

α-aminolauric acid

isopropanol

→

α-Aminolauric acid isopropyl ester

反应条件

后处理

1. 1
   温度to reflux for two hours
2. 2
   温度After cooling off to room temperature
3. 3
   浓缩the batch is completely concentrated by evaporation
4. 4
   workup.STIRRINGshaken out from aqueous sodium carbonate solution
5. 5
   其他The organic phase is dried on magnesium sulfate
6. 6
   过滤filtered
7. 7
   浓缩concentrated by evaporation

实验过程

50 ml of isopropanol is stirred at 0° C. under argon and mixed drop by drop with 3.12 ml (41.6 mmol) of thionyl chloride. 30 minutes later, 7.40 g (34.4 mmol) of α-aminolauric acid is added in portions, stirred for one hour at room temperature and the batch then is allowed to reflux for two hours. After cooling off to room temperature, the batch is completely concentrated by evaporation, the residue is taken up in tert-butyl methyl ether and shaken out from aqueous sodium carbonate solution. The organic phase is dried on magnesium sulfate, filtered and concentrated by evaporation.

来源