反应 #1466013

反应方程式

4-(3-oxo-3H-benzo[d]isothiazol-2-yl)benzene sulfonamide

methyl thiosalicylate

→

title compound

收率 92.7%

2-[2-(4-Sulfamoylphenylcarbamoyl)phenyldisulfanyl]benzoic acid, methyl ester

收率 92.7%

溶剂

methanol

tetrahydrofuran

反应条件

后处理

1. 1
   其他This compound was prepared
2. 2
   其他The product was triturated with ether
3. 3
   过滤filtered
4. 4
   洗涤washed with ether
5. 5
   其他dried in vacuo

实验过程

This compound was prepared according to the method of Example 132 using a suspension of 0.46 g (1.5 mmol) of 4-(3-oxo-3H-benzo[d]isothiazol-2-yl)benzene sulfonamide in a mixture of 15 mL of methanol and 15 mL of tetrahydrofuran, and 0.27 g (1.6 mmol) of methyl thiosalicylate. The product was triturated with ether, filtered, washed with ether and dried in vacuo to give 0.66 g of the title compound, mp 288°-290° C.

来源