反应 #1464737

反应方程式

sodium hydrogen carbonate

n-Butyllithium

2-bromothiazole

2-acetylthiazole

→

title compound

1,1-Di(2-thiazolyl)ethanol

溶剂

diethyl ether

diethyl ether

反应条件

后处理

1. 1
   workup.WAITAfter a further 1 hour
2. 2
   workup.WAITAfter 1 hour
3. 3
   其他the organic phase was separated

实验过程

n-Butyllithium (2.5M solution in hexanes, 17.3 ml) was added dropwise to a stirred solution of 2-bromothiazole (6.5 g) in anhydrous diethyl ether (40 ml) at -70° C. under an atmosphere of dry nitrogen. After 30 minutes, 2-acetylthiazole (5 g) in diethyl ether (10 ml) was added dropwise. After a further 1 hour, the mixture was allowed to warm to room temperature. After 1 hour, saturated aqueous sodium hydrogen carbonate solution was added and the organic phase was separated. Further processing in the usual fashion then gave the title compound.

来源