反应 #1463486

反应方程式

cyclohexane

4-(4-propylcyclohexyl)cyclohexane

acetone

water

→

3-(4-(4-propylcyclohexyl)cyclohexyl)-2E-propenal

溶剂

hydrochloric acid

反应条件

后处理

1. 1
   温度by heating the solution
2. 2
   温度under reflux for 4 hours
3. 3
   萃取extracting with ether (50 ml)
4. 4
   干燥drying the organic layer over anhydrous magnesium sulfate
5. 5
   浓缩concentrating under reduced pressure

实验过程

The resulting cyclohexane derivative was dissolved in a mixed solvent of acetone (80 ml) with 2N hydrochloric acid (8 ml), followed by heating the solution under reflux for 4 hours, cooling the reaction mixture down to room temperature after completion of the stirring, adding water, extracting with ether (50 ml), drying the organic layer over anhydrous magnesium sulfate, and concentrating under reduced pressure to obtain 3-(4-(4-propylcyclohexyl)cyclohexyl)-2E-propenal (3.1 g, 12 mmols). This product was used in the subsequent reaction without any purification.

来源