反应 #1447090

反应方程式

N-(Diphenylmethylene)glycine ethyl ester

3,4,5-trifluorobenzylbromide

potassium carbonate

→

title compound

收率 72.9%

N-(Diphenylmethylene) (3,4,5-trifluoro)-D,L-Phenylalanine ethyl ester

收率 72.9%

溶剂

dimethylformamide

反应条件

后处理

1. 1
   过滤The mixture was filtered
2. 2
   其他the filtrate was evaporated to dryness
3. 3
   其他to give crude product
4. 4
   其他It was purified by column chromatography on silica gel (hexane:ethyl acetate=4:1)

实验过程

A solution of N-(Diphenylmethylene)glycine ethyl ester (1.10 g, 4.1 mmol) and 3,4,5-trifluorobenzylbromide (0.91 g, 4.0 mmol) in dimethylformamide (10 mL) was treated with anhydrous potassium carbonate (2.83 g, 20.5 mmol) and stirred for 18 hrs at 25° C. The mixture was filtered and the filtrate was evaporated to dryness to give crude product. It was purified by column chromatography on silica gel (hexane:ethyl acetate=4:1) to give title compound (1.2 g).

来源