反应 #1447087

反应方程式

D-Homophenylalanine Benzyl ester Tosylate

sodium bicarbonate

→

D-Homophenylalanine Benzyl ester

溶剂

water

ethyl acetate

反应条件

后处理

1. 1
   萃取The water layer was extracted with ethyl acetate (3×10 mL)
2. 2
   萃取The combined organic extract
3. 3
   干燥was dried over anhydrous sodium sulfate
4. 4
   过滤filtered
5. 5
   浓缩concentrated to dryness

实验过程

D-Homophenylalanine Benzyl ester Tosylate (2.48 g, 5.6 mmol) was suspended in ethyl acetate (25 mL) and a saturated solution of sodium bicarbonate in water was added in portions (25 mL) with stirring at 25° C. The water layer was extracted with ethyl acetate (3×10 mL). The combined organic extract was dried over anhydrous sodium sulfate, filtered and concentrated to dryness to afford D-Homophenylalanine Benzyl ester. The ester was dissolved in acetonitile (25 mL). NαNδ-bis-Boc-L-Ornithine (2.0 g, 6.0 mmol) was then added followed by N-hydroxysuccinimide (50 mg) and dicyclohexylcarbodiimide (1.28 g, 6.2 mmol). The reaction was stirred at 25° C. for 30 hr. filtered and the filtrate concentrated to dryness to afford crude product. It was purified by column chromatography on silica gel (hexane:ethyl acetate=3:1), which gave the title product (2.80 g) as white solid.

来源