反应 #1447084

反应方程式

N-(2-hydroxy-1-methylcarbamoylbut-3-enyl)-1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxamide

acetic acid

dimethylaminopyridine

→

1-{Methylcarbamoyl-[(1-methyl-3-trifluoromethyl-1H-pyrazole-4-carbonyl)amino]-methyl}allyl acetate

溶剂

CH2Cl2

反应条件

后处理

1. 1
   洗涤the reaction solution was washed
2. 2
   其他the solvent was removed

实验过程

134 mg (0.42 mmol) of N-(2-hydroxy-1-methylcarbamoylbut-3-enyl)-1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxamide, 28 mg (0.46 mmol) of acetic acid and 20 mg (0.17 mmol) of dimethylaminopyridine were dissolved in CH2Cl2. At 0° C., 88 mg (0.46 mmol) of 1-(3-dimethylaminopropyl)-3-(ethylcarbodiimide) hydrochloride were added. After 16 h of stirring at RT, the reaction solution was washed and the solvent was removed. This gave 0.10 g (66% of theory) of the title compound as a colorless powder (M+(m/z)=362).

来源