反应 #1447075

反应方程式

HCl

Caprolactone

potassium hydroxide

methanol

→

6-hydroxyhexanoic acid

溶剂

THF

反应条件

后处理

1. 1
   萃取extracted with ethyl acetate
2. 2
   洗涤The combined organic layers were washed with water
3. 3
   其他dried
4. 4
   过滤filtered
5. 5
   浓缩concentrated

实验过程

Caprolactone (100 g) was added to a mixture of potassium hydroxide (145 g), methanol (110 mL), and THF (390 mL). The resulting mixture was stirred at room temperature overnight. The solution was then acidified with HCl and extracted with ethyl acetate. The combined organic layers were washed with water, dried, filtered, and concentrated to obtain 6-hydroxyhexanoic acid. 1H NMR (CDCl3, 500 MHz) δ 1.44 (m, 2H), 1.60 (m, 2H), 1.68 (m, 2H), 2.37 (t, J=7.5 Hz, 2H), 3.66 (t, J=6.5 Hz, 2H), 5.80 (br, 1H).

来源