反应 #1435775

反应方程式

(S)-2,2-dioxo-2λ6-[1,2,3]oxathiazolidine-3,4-dicarboxylic acid 4-benzyl ester 3-tert-butyl ester

2-methyl-6-nitro-phenol

sodium hydride

→

title compound

收率 33.0%

(S)-2-tert-Butoxycarbonylamino-3-(2-methyl-6-nitro-phenoxy)-propionic acid benzyl ester

收率 33.0%

溶剂

N,N-dimethylformamide

反应条件

后处理

1. 1
   workup.ADDITIONAfter complete addition
2. 2
   workup.STIRRINGstirring
3. 3
   workup.WAITcontinued at 0° C. for 3 hours
4. 4
   其他at room temperature
5. 5
   其他overnight
6. 6
   其他the solvent was evaporated under reduced pressure
7. 7
   workup.ADDITIONthe residue treated with 100 ml of hydrochloric acid (1 N)
8. 8
   萃取extracted 3 times with 150 ml of ethyl acetate
9. 9
   其他The crude product (4.0 g) was obtained as a dark brown oil which
10. 10
    其他was purified by flash-chromatography on silica gel using a gradient of a 100%
11. 11
    workup.ADDITION0%- to 50%:50%-mixture of heptane and ethyl acetate as the eluent

实验过程

In an inert atmosphere and under exclusion of moisture, at 0° C. a solution of 1.5 g (10 mmol) of 2-methyl-6-nitro-phenol [Ger.Offen. 3536192] in 30 ml of N,N-dimethylformamide was treated portionwise with 0.42 g (18 mmol) of sodium hydride (55% dispersion in mineral oil). After complete addition, stirring was continued for 1 hour at 0° C. Thereafter, 3.85 g (11 mmol) of (S)-2,2-dioxo-2λ6-[1,2,3]oxathiazolidine-3,4-dicarboxylic acid 4-benzyl ester 3-tert-butyl ester was added and stirring continued at 0° C. for 3 hours, then at room temperature overnight. For the working-up, the solvent was evaporated under reduced pressure, the residue treated with 100 ml of hydrochloric acid (1 N), then extracted 3 times with 150 ml of ethyl acetate. The crude product (4.0 g) was obtained as a dark brown oil which was purified by flash-chromatography on silica gel using a gradient of a 100%:0%- to 50%:50%-mixture of heptane and ethyl acetate as the eluent. There were obtained 1.4 g (33%) of the title compound as an yellow oil, [α]589=−1.45° (c=1.0% in MeOH), MS m/e (%): 431.4 (M+H+, 13).

来源