反应 #1435763

反应方程式

2-Methyl-N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acid ethyl ester

lithium hydroxide

→

2-Methyl-N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acid

溶剂

tetrahydrofurane

water

反应条件

后处理

1. 1
   浓缩After concentration in vacuo water (50 ml)
2. 2
   workup.ADDITIONwas added
3. 3
   萃取the mixture was extracted with dichloromethane (three times 30 ml)
4. 4
   萃取extracted with dichloromethane (three times 30 ml)

实验过程

To a solution of 1.8 g (6.5 mmol) 2-Methyl-N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acid ethyl ester in 40 ml of tetrahydrofurane, 20 ml of water and 1.09 g (26 mmol) of lithium hydroxide were added and the mixture was stirred overnight at room temperature. After concentration in vacuo water (50 ml) was added and the mixture was extracted with dichloromethane (three times 30 ml). The aqueous phase was acidified with 8 N hydrochloric acid and extracted with dichloromethane (three times 30 ml).

来源