反应 #1435758

反应方程式

2-(4-aminobutyl)-1,2,3,4-tetrahydroisoquinoline dihydrochloride

N,N-diisopropylethylamine

naphtalene-1-sulfonyl chloride

→

solid

收率 72.0%

Naphthalene-1-sulfonic acid [4-(3,4-dihydro-1H-isoquinolin-2-yl)-butyl]amide hydrochloride

收率 72.0%

溶剂

CH2Cl2

反应条件

后处理

1. 1
   洗涤The resulting solution was washed with water (3×15 mL)
2. 2
   干燥dried over Na2SO4
3. 3
   其他evaporated to dryness
4. 4
   workup.DISSOLUTIONThe free base was dissolved in 2-propanol (5 mL)
5. 5
   workup.ADDITIONA 2.8 M solution of hydrogen chloride in ethanol (0.40 mL) was then added
6. 6
   其他The product was crystallized
7. 7
   过滤collected by filtration, and vacuum
8. 8
   其他dried

实验过程

A solution of 2-(4-aminobutyl)-1,2,3,4-tetrahydroisoquinoline dihydrochloride (272 mg, 1 mmol), N,N-diisopropylethylamine (517 mg, 4 mmol) in CH2Cl2 (10 mL), was added naphtalene-1-sulfonyl chloride (238 mg, 1.05 mmol) and was stirred overnight at room temperature. The resulting solution was washed with water (3×15 mL) and dried over Na2SO4, and evaporated to dryness. The free base was dissolved in 2-propanol (5 mL). A 2.8 M solution of hydrogen chloride in ethanol (0.40 mL) was then added. The product was crystallized and collected by filtration, and vacuum dried to give a white solid (310 mg, 72%).

来源