反应 #1435740

反应方程式

4-iodo-6-(4-methyl-piperazin-1-yl)-pyridin-3-ylamine

N,N-diisopropyl ethyl amine

2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride

→

crude title compound

收率 112.3%

2-(3,5-Bis-trifluoromethyl-phenyl)-N-[4-iodo-6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-isobutyramide

收率 112.3%

溶剂

dichloromethane

反应条件

后处理

1. 1
   温度at reflux
2. 2
   温度After cooling to room temperature the reaction mixture
3. 3
   洗涤was washed with 20 ml of a 1 M aqueous sodium carbonate solution and 20 ml water
4. 4
   干燥The combined organic layers were dried over sodium sulfate
5. 5
   浓缩concentrated in vacuo

实验过程

To a suspension of 1.60 g (5.03 mmol) 4-iodo-6-(4-methyl-piperazin-1-yl)-pyridin-3-ylamine and 975 mg (7.54 mmol) N,N-diisopropyl ethyl amine in 16 ml dichloromethane was added dropwise 1.76 g (5.53 mmol) 2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride at 0° C. The reaction mixture was stirred for 2 h at room temperature and 2 h at reflux. After cooling to room temperature the reaction mixture was washed with 20 ml of a 1 M aqueous sodium carbonate solution and 20 ml water. The combined organic layers were dried over sodium sulfate and concentrated in vacuo to give 3.39 g (100%) of the crude title compound as a brown oil.

来源