反应 #1435726

反应方程式

ammonium chloride

5,7-dichloro-6-(2,4,6-trifluorophenyl)imidazo[1,2-a]pyrimidine

4-methylpiperidine

→

5-(4-methylpiperidin-1-yl)-6-(2,4,6-trifluorophenyl)-7-chloroimidazo[1,2-a]pyrimidine

收率 80.9%

溶剂

chloroform

反应条件

后处理

1. 1
   温度Under ice-cooling
2. 2
   洗涤The separated organic layer was washed with water
3. 3
   干燥dried over sodium sulfate
4. 4
   浓缩concentrated
5. 5
   洗涤The residue was washed with t-butyl methyl ether

实验过程

Under ice-cooling, 0.64 g of 5,7-dichloro-6-(2,4,6-trifluorophenyl)imidazo[1,2-a]pyrimidine and 0.79 g of 4-methylpiperidine were mixed. The mixture was allowed to stand at room temperature for one hour, and chloroform and aqueous saturated ammonium chloride solution were added to the reaction mixture. The separated organic layer was washed with water, dried over sodium sulfate and concentrated. The residue was washed with t-butyl methyl ether to give 0.62 g of 5-(4-methylpiperidin-1-yl)-6-(2,4,6-trifluorophenyl)-7-chloroimidazo[1,2-a]pyrimidine

来源