反应 #1435725

反应方程式

diethyl (2,4,6-trifluorophenyl)malonate

2-aminoimidazole hydrochloride

DBU

N,N-dimethylformamide

→

5,7-dihydroxy-6-(2,4,6-trifluorophenyl)imidazo[1,2-a]pyrimidine

收率 78.3%

溶剂

water

chloroform

反应条件

后处理

1. 1
   温度to cool to room temperature
2. 2
   浓缩The separated water layer was concentrated
3. 3
   workup.ADDITIONthe residue was diluted with water and conc. hydrochloric acid
4. 4
   workup.ADDITIONwas added
5. 5
   温度under ice-cooling
6. 6
   其他The precipitation
7. 7
   过滤was filtered
8. 8
   其他dried

实验过程

A mixture of 2.90 g of diethyl (2,4,6-trifluorophenyl)malonate, 2.39 g of 2-aminoimidazole hydrochloride, 4.57 g of DBU and 10 ml of N,N-dimethylformamide was heated at 100° C. for 6 hours. After allowing the reaction mixture to cool to room temperature, chloroform and water were added thereto. The separated water layer was concentrated, the residue was diluted with water and conc. hydrochloric acid was added thereto under ice-cooling. The precipitation was filtered and dried to give 2.2 g of 5,7-dihydroxy-6-(2,4,6-trifluorophenyl)imidazo[1,2-a]pyrimidine.

来源