反应 #1435697

反应方程式

ethanol

cysteine hydrochloride

maltose

Ethanol

pyridine

→

2-(1,2,4,5-Tetrahydroxy-3-Glucopyranosyloxypentyl) Thiazolidine-4-Carboxylic acid

溶剂

water

反应条件

后处理

1. 1
   workup.WAITthe solution was left
2. 2
   其他was formed
3. 3
   其他The solvent was removed by decantation
4. 4
   workup.DISSOLUTIONthe precipitate was dissolved in 100 ml of water
5. 5
   其他After the insoluble matters were removed by filtration
6. 6
   其他condensed to about 30 ml
7. 7
   workup.WAITthe solution was then left
8. 8
   其他to stand in a refrigerator overnight
9. 9
   过滤The produced crystals were collected by filtration
10. 10
    workup.DISSOLUTIONThe crystals were then dissolved in water again
11. 11
    其他the insoluble matters were removed by filtration
12. 12
    其他condensed, and ethanol
13. 13
    workup.ADDITIONwas added to the solution
14. 14
    其他recrystallization
15. 15
    过滤The produced crystals were collected by filtration
16. 16
    其他dried under reduced pressure
17. 17
    其他to obtain 2.2 g of a white powder (molar yield based on cysteine: 4.9%)

实验过程

17.56 Grams (100 mmol) of cysteine hydrochloride and 34.20 g (100 mmol) of maltose were dissolved in 35 ml of pure water, 8.36 ml (100 mmol) of pyridine was then added thereto, and the resulting solution was stirred at room temperature for 72 hours. 300 Milliliters of ethanol was added to the stirred solution, and the solution was left to stand in a refrigerator, whereby a paste-like precipitate was formed. The solvent was removed by decantation, and the precipitate was dissolved in 100 ml of water. After the insoluble matters were removed by filtration, the remaining solution was condensed to about 30 ml. Ethanol was continuously added to the condensed solution until a precipitate was about to appear, and the solution was then left to stand in a refrigerator overnight. The produced crystals were collected by filtration. The crystals were then dissolved in water again, the insoluble matters were removed by filtration, the resulting solution was condensed, and ethanol was added to the solution to cause recrystallization. The produced crystals were collected by filtration and dried under reduced pressure to obtain 2.2 g of a white powder (molar yield based on cysteine: 4.9%).

来源