反应 #1435691

反应方程式

trifluoroacetic acid ethyl ester

1,4,7-triazaheptane

→

1,7-Bis(trifluoroacetyl)-1,4,7-triazaheptane

溶剂

tetrahydrofuran

反应条件

后处理

1. 1
   浓缩concentrated by evaporation in a vacuum
2. 2
   其他The remaining oil is crystallized from hexane

实验过程

113.3 g (790 mmol) of trifluoroacetic acid ethyl ester is added in drops to a solution consisting of 41.14 g (390 mmol) of 1,4,7-triazaheptane in 350 ml of tetrahydrofuran at 80° C. and under nitrogen. It is allowed to stir overnight at room temperature, concentrated by evaporation in a vacuum. The remaining oil is crystallized from hexane.

来源