反应 #1435684

反应方程式

sodium hydroxide

bis(2-chloroethyl) (4-methoxy-5-methyl-1,3-phenylene)biscarbamate

hydrochloric acid

→

3,3′-(4-methoxy-5-methyl-1,3-phenylene)bis(1,3-oxazolidin-2-one)

溶剂

dioxane

反应条件

后处理

1. 1
   workup.STIRRINGAfter stirring overnight at room temperature
2. 2
   workup.ADDITIONthe mixture was poured onto ice
3. 3
   过滤The precipitated product was filtered off with suction
4. 4
   其他dried overnight under reduced pressure

实验过程

200 ml of sodium hydroxide solution (20% strength) were initially introduced and heated to 45° C. Subsequently, 59 g of bis(2-chloroethyl) (4-methoxy-5-methyl-1,3-phenylene)biscarbamate were added in portions and the mixture was diluted with 200 ml of dioxane. The mixture was after-stirred for a further 2 h at 45° C. After stirring overnight at room temperature, the mixture was poured onto ice, and the mixture was neutralized with hydrochloric acid. The precipitated product was filtered off with suction and dried overnight under reduced pressure.

来源