反应 #1394

反应方程式

trimethylpyruvic acid sodium salt

hydroxylamine hydrochloride

→

trimethylpyruvic acid oxime

收率 81.2%

溶剂

water

反应条件

后处理

1. 1
   其他The product crystallized out
2. 2
   温度during slow cooling under agitation
3. 3
   过滤After 1.5 h agitation in an ice bath the crystals were filtered off
4. 4
   洗涤washed with 150 ml ice water
5. 5
   其他dried in a vacuum at 60° C.
6. 6
   干燥further dried in a vacuum desiccator over phosphorus pentaoxide to constant weight

实验过程

163 g (1 mole) 93.5% trimethylpyruvic acid sodium salt and 69.5 g (1 mole) hydroxylamine hydrochloride were dissolved at 40° C. in 450 ml water. The product crystallized out during slow cooling under agitation. After 1.5 h agitation in an ice bath the crystals were filtered off, washed with 150 ml ice water, dried in a vacuum at 60° C., and then further dried in a vacuum desiccator over phosphorus pentaoxide to constant weight. 117.8 g trimethylpyruvic acid oxime (81% yield) in the form of colorless crystals were obtained.

来源