反应 #1381

反应方程式

Methyl 2-methyl-3-nitrobenzoate

→

methyl 2-methyl-3-aminobenzoate

收率 101.6%

溶剂

acetic acid

反应条件

后处理

1. 1
   其他at room temperature
2. 2
   过滤the catalyst is filtered off
3. 3
   浓缩The reaction mixture is concentrated
4. 4
   workup.ADDITIONis added water
5. 5
   萃取followed by extraction with dichloromethane
6. 6
   浓缩The solvent is concentrated

实验过程

Methyl 2-methyl-3-nitrobenzoate (10.0 g) is dissolved in acetic acid (50 ml) and thereto 5% Pd-C (1 g) is added to carry out catalytic reduction at room temperature under 1 atm. After 1.5 hours, the catalyst is filtered off. The reaction mixture is concentrated, and thereto is added water, and the mixture is made alkaline with potassium carbonate, followed by extraction with dichloromethane. The solvent is concentrated to give methyl 2-methyl-3-aminobenzoate (8.6 g).

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