反应 #1379895

反应方程式

acryloyl chloride

O-benzyl hydroxylamine hydrochloride

Water

→

N-benzyloxyacrylamide

溶剂

dichloromethane

dichloromethane

反应条件

后处理

1. 1
   其他the layers were separated
2. 2
   洗涤The organic solution was washed with diluted hydrochloric acid
3. 3
   干燥The organic layer was dried over magnesium sulfate
4. 4
   过滤filtered
5. 5
   其他the solvent removed under reduced pressure
6. 6
   其他The residue was purified by flash chromatography
7. 7
   workup.ADDITIONa mixture of hexane and ethyl acetate
8. 8
   其他The purification

实验过程

A solution of acryloyl chloride dissolved in dry dichloromethane was cooled at 0° C. with an ice bath. A mixture of O-benzyl hydroxylamine hydrochloride (29) and N,N-diisopropylethylaamine in dry dichloromethane was added. Water was added and the layers were separated. The organic solution was washed with diluted hydrochloric acid, a saturated sodium bicarbonate solution, water, and brine. The organic layer was dried over magnesium sulfate, filtered, and the solvent removed under reduced pressure. The residue was purified by flash chromatography using a mixture of hexane and ethyl acetate. The purification gave N-benzyloxyacrylamide (30).

来源