反应 #1371

反应方程式

diethyl 2-methyl-3,4,6-trifluorobenzoylmalonate

p-toluenesulfonic acid

→

ethyl 2-methyl-3,4,6-trifluorobenzoylacetate

收率 82.6%

溶剂

water

反应条件

后处理

1. 1
   温度the mixture is refluxed for 2.5 hours
2. 2
   温度After cooling
3. 3
   萃取the resultant is extracted with diethyl ether
4. 4
   干燥the extract is dried over magnesium sulfate
5. 5
   浓缩concentrated

实验过程

To diethyl 2-methyl-3,4,6-trifluorobenzoylmalonate (5.1 g) are added water (20 ml) and p-toluenesulfonic acid (30 mg) and the mixture is refluxed for 2.5 hours. After cooling, the resultant is extracted with diethyl ether, and the extract is dried over magnesium sulfate and concentrated to give ethyl 2-methyl-3,4,6-trifluorobenzoylacetate (3.3 g).

来源