反应 #1365751

反应方程式

solution

[(3S,4S)-4-(1-Cyclopentyl-3-ethyl(1H-indazol-6-yl))-3-methyl-1-benzylpyrrolidin-3-yl]methan-1-ol

→

pyrrolidine

收率 71.0%

[(3S,4S)-4-(1-Cyclopentyl-3-ethyl(1H-indazol-6-yl))-3-methylpyrrolidin-3-yl]methan-1-ol

收率 71.0%

溶剂

ethanol

反应条件

后处理

1. 1
   其他Hydrogen was vigorously bubbled through the solution for 5 minutes
2. 2
   其他the catalyst was removed by filtration through celite
3. 3
   其他The solvent then was removed in vacuo

实验过程

To a stirred solution of Example 3 (25.5 mg; 0.0611 mmol) in 190 proof ethanol (2.0 mL) was added 10% Pd/C (5 mg; 20 wt. % catalyst). Hydrogen was vigorously bubbled through the solution for 5 minutes. The reaction was allowed to stir at room temperature for 2 hours, then the catalyst was removed by filtration through celite. The solvent then was removed in vacuo to provide the named pyrrolidine (14 mg; 71%).

来源