反应 #1365745

反应方程式

product

Methyl 2-Pyrazine Carboxylate

hydrazine

→

required product

Pyrazine-2-hydrazide

溶剂

methanol

反应条件

后处理

1. 1
   其他The precipitate produced
2. 2
   过滤was filtered
3. 3
   洗涤washed with diethyl ether
4. 4
   其他dried in the oven at 80° C.

实验过程

To a solution of the product from Example 1 step c) (22 g, 159 mmol) in methanol (250 ml) was slowly added hydrazine monhydrate (36.6 ml, 710 mmol). The reaction mixture was stirred for 1.5 h. The precipitate produced was filtered, washed with diethyl ether and dried in the oven at 80° C. to give the required product (30 g). 1H NMR (250 MHz, DMSO) δ 4.66 (2H, broad peak), 8.66 (1H, m), 8.84 (1H, d, J=2.5 Hz), 9.13 (1H, d, J=2.5 Hz), 10.15 (1H, broad peak); MS (ES+) m/e 139 [MH+].

来源