反应 #1365744

反应方程式

Acetyl chloride

pyrazine-2-carboxylic acid

→

required product

Methyl 2-Pyrazine Carboxylate

溶剂

methanol

methanol

反应条件

后处理

1. 1
   workup.ADDITIONwas added
2. 2
   workup.WAITThe reaction mixture was left
3. 3
   其他The methanol was removed in vacuo

实验过程

Acetyl chloride (50 ml) was added very slowly to methanol (500 ml), and the mixture was allowed to cool before pyrazine-2-carboxylic acid (15 g, 124 mmol) in methanol (15 ml) was added. The reaction mixture was left to stand at room temperature overnight. The methanol was removed in vacuo to give the required product (22 g). 1H NMR (250 MHz, DMSO) δ 3.95 (3H, s), 8.82 (1H, m), 8.90 (1H, d, J=2.5 Hz), 9.21 (1H, d, J=2.5 Hz); MS (ES+) m/e 153 [MH+].

来源