反应 #1365742

反应方程式

2-mercaptopyrimidine

1-bromo-5-chloropentane

triethylamine

→

product

收率 52.0%

2-(5-Chloropentylmercapto)pyrimidine

收率 52.0%

溶剂

THF

反应条件

后处理

1. 1
   温度After cooling
2. 2
   过滤filtration
3. 3
   浓缩with suction and concentration
4. 4
   其他the residue was purified by chromatography (mobile phase: cyclohexane/ethyl acetate=92/8)

实验过程

2.8 g (25=mol) of 2-mercaptopyrimidine, 4.64 g (25 mmol) of 1-bromo-5-chloropentane and 2.58 g (25.5 mmol) of triethylamine in 100 ml of THF were refluxed for 4 hours. After cooling, filtration with suction and concentration, the residue was purified by chromatography (mobile phase: cyclohexane/ethyl acetate=92/8). 2.8 g of product were obtained (=52% yield).

来源