反应 #1365731

ord-de10881907ed4ef0a57acda5aa179634

反应方程式

[Na]
sodium
CC(C)=CCC[C@]1(C)[C@@H](CC=C(C)C)C[C@@]2(CC=C(C)C)C(=O)[C@]1(C(=O)C(C)C)C(=O)C(CC=C(C)C)=C2O
hyperforin
→
CC(C)=CCC[C@]1(C)[C@@H](CC=C(C)C)C[C@@]2(CC=C(C)C)C(=O)[C@]1(C(=O)C(C)C)C(=O)C(CC=C(C)C)=C2O.[Na]
Hyperforin Sodium

反应物

[Na]
sodium
CC(C)=CCC[C@]1(C)[C@@H](CC=C(C)C)C[C@@]2(CC=C(C)C)C(=O)[C@]1(C(=O)C(C)C)C(=O)C(CC=C(C)C)=C2O
hyperforin

试剂

无

溶剂

CO
methanol

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他the solution evaporated
  2. 2
    workup.DISSOLUTIONThe residue is dissolved in 100 ml water
  3. 3
    其他from 170° C

实验过程

23 mg (1 mmol) sodium is dissolved in 50 ml anhydrous methanol. 536 mg (1 mmol) hyperforin is dissolved in this solution under stirring, and the solution evaporated. The residue is dissolved in 100 ml water and lyophilised. Yield: 556 mg of a light-coloured powder (99.6% of theoretical). Mp.: Degradation from 170° C. IR: 1420-1500 cm−(sv).

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US06444662B1uspto-grants-2002_09