反应 #1365726

反应方程式

n-Propyl isocyanate

7-fluoro-6-amino-4-(2-propynyl)-2H-1,4-benzoxazin-3(4H)-one

n-propyl isocyanate

→

N-n-propyl-N′-[7-fluoro-4-(2-propynyl)-2H-1,4-benzoxazin-3(4H)-one-6-yl]urea

溶剂

dioxane

反应条件

后处理

1. 1
   温度the reaction mixture was maintained at 80° C. overnight
2. 2
   浓缩Then the solution was concentrated to dryness

实验过程

n-Propyl isocyanate (1.0 g, 11.7 mmol) was added to a solution of 7-fluoro-6-amino-4-(2-propynyl)-2H-1,4-benzoxazin-3(4H)-one (0.20 g, 0.9 mmol) in dioxane (20 mL) with stirring. The reaction mixture was heated to 80° C. for 4 hours. More n-propyl isocyanate (0.43 g, 5 mmol) was added and the reaction mixture was maintained at 80° C. overnight. Then the solution was concentrated to dryness to afford N-n-propyl-N′-[7-fluoro-4-(2-propynyl)-2H-1,4-benzoxazin-3(4H)-one-6-yl]urea as a crude intermediate (1.1 g). This was used for the next step without further purification.

来源