反应 #1365725

反应方程式

2-fluoro-4-chloro-5-methoxycarbonylaniline

diphosgene

→

2-fluoro-4-chloro-5-methoxycarbonylphenyl isocyanate

收率 95.8%

溶剂

THF

toluene

反应条件

后处理

1. 1
   workup.STIRRINGThe reaction mixture was stirred at room temperature for one hour
2. 2
   温度heated
3. 3
   温度to reflux for 4 hours
4. 4
   温度The mixture was then cooled to room temperature
5. 5
   其他the solvents were evaporated under reduced pressure

实验过程

A solution of 2-fluoro-4-chloro-5-methoxycarbonylaniline (1.0 g, 5 mmol) in THF (10 mL) was added dropwist to a solution of diphosgene (2.0 g, 10 mmol) in toluene (20 mL) with stirring at room temperature. The reaction mixture was stirred at room temperature for one hour and then heated to reflux for 4 hours. The mixture was then cooled to room temperature and the solvents were evaporated under reduced pressure to give 1.1 g of 2-fluoro-4-chloro-5-methoxycarbonylphenyl isocyanate as a solid. This was used for the next step without further purification.

来源