反应 #1365724

反应方程式

2-fluoro-4-chloro-5-cyclopentyloxyaniline

oxalyl chloride

HCl

→

2-fluoro-4-chloro-5-cylcopentyloxyphenyl isocyanate

收率 86.0%

溶剂

toluene

toluene

反应条件

后处理

1. 1
   workup.STIRRINGThe reaction mixture was stirred at room temperature for 1 hour
2. 2
   温度heated
3. 3
   其他the solvents were removed at reduced pressure

实验过程

A solution of 2-fluoro-4-chloro-5-cyclopentyloxyaniline (1.0 g, 5 mmol) in toluene (50 mL) was added dropwise to a solution of oxalyl chloride (2.0 g, 10 mmol) in toluene (20 mL) with stirring. The reaction mixture was stirred at room temperature for 1 hour and then heated to reflux for 4 hours until HCl evolution ceased. The mixture was cooled down to room temperature and the solvents were removed at reduced pressure to give 1.1 g of 2-fluoro-4-chloro-5-cylcopentyloxyphenyl isocyanate as an oily product. This was used in the next step without further purification.

来源