反应 #1365722

反应方程式

water

dibromoethane

indene

n-butyllithium

→

1.2-bisindenylethane

收率 51.6%

溶剂

tetrahydrofuran

tetrahydrofuran

反应条件

后处理

1. 1
   温度to heat up to room temperature
2. 2
   温度It was cooled to −78° C.
3. 3
   workup.ADDITIONwere dropped (within 20 minutes)
4. 4
   workup.ADDITIONAfter the end of the addition
5. 5
   温度the temperature was raised to 50° C.
6. 6
   workup.STIRRINGunder stirring for 12 hours
7. 7
   温度was cooled down to room temperature
8. 8
   其他The organic phase was dried
9. 9
   萃取the residue was extracted with pentane
10. 10
    其他By evaporation under vacuum 28.65 g of product
11. 11
    其他were obtained (yield=51.6%)

实验过程

Into a 2 liter two-necked round-bottomed flask, 50 g of indene (437 mmol) were dissolved under inert atmosphere with 500 ml of tetrahydrofuran and were cooled to −78°C. By slow dropping (1 hour) 175 ml of n-butyllithium (2.5M in hexane, 437.5 mmol) were added. The mixture was allowed to heat up to room temperature and was kept under stirring for 4 hours. It was cooled to −78° C. and 40.42 g of dibromoethane (215 mmol) dissolved in 100 ml of tetrahydrofuran were dropped (within 20 minutes). After the end of the addition, the temperature was raised to 50° C., the whole was kept under stirring for 12 hours, then was cooled down to room temperature and 20 ml of water were added. The organic phase was dried and the residue was extracted with pentane. By evaporation under vacuum 28.65 g of product were obtained (yield=51.6%).

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