反应 #1365716

反应方程式

Z-Asp(OtBu)-Leu-OBzl

→

H-Asp(OtBu)-Leu-OH

收率 89.7%

溶剂

methanol

反应条件

后处理

1. 1
   过滤After filtering off the catalyst
2. 2
   浓缩the filtrate was concentrated
3. 3
   其他to give a foamy solid
4. 4
   其他The crude product was triturated with diethyl ether

实验过程

The Z-Asp(OtBu)-Leu-OBzl (15.6 g) in methanol (50 mL) was added 10% Pd on carbon (0.17 g) and was hydrogenated on a Paar Shaker. After filtering off the catalyst, the filtrate was concentrated to give a foamy solid. The crude product was triturated with diethyl ether to yield 8.03 g of H-Asp(OtBu)-Leu-OH.

来源