反应 #1363

反应方程式

11,15-dihydroxy-13-sulfoethyl-9,13,17-triazapentacosane

succinic anhydride

→

6,10-dihydroxy-4,12-dioctyl-3,13-dioxo-8-sulfoethyl-4,8,12-triaza-1,15-pentadecanedicarboxylic acid

收率 80.5%

溶剂

xylene

反应条件

后处理

1. 1
   workup.ADDITIONwere then added
2. 2
   其他a reaction at 50° C. for 6 hours
3. 3
   workup.DISTILLATIONAfter xylene was distilled off under reduced pressure, 300 ml of water
4. 4
   workup.ADDITIONwere added
5. 5
   workup.ADDITION10% sodium hydroxide was further added

实验过程

A reactor was charged with 27 g (0.05 mole) of 11,15-dihydroxy-13-sulfoethyl-9,13,17-triazapentacosane and 100 g of xylene, to which 12 g (0.12 mole) of succinic anhydride were then added with stirring to conduct a reaction at 50° C. for 6 hours. After xylene was distilled off under reduced pressure, 300 ml of water were added, and 10% sodium hydroxide was further added to keep the pH of the reaction mixture at 7. Thereafter, the reaction mixture was subjected to electrodialysis and lyophilized, thereby obtaining 28 g (isolation yield: 76%) of 6,10-dihydroxy-4,12-dioctyl-3,13-dioxo-8-sulfoethyl-4,8,12-triaza-1,15-pentadecanedicarboxylic acid as white crystals.

来源