反应 #1350589

反应方程式

N-(2-methyl-3-methoxycarbonylphenyl)thiourea

bromine

→

Methyl 2-Amino-4-methylbenzothiazole-5-carboxylate

溶剂

chlorobenzene

chlorobenzene

反应条件

后处理

1. 1
   温度The reaction mixture was heated at 90° C. for 3 h
2. 2
   过滤the precipitate was filtered off with suction
3. 3
   洗涤washed with methylene chloride
4. 4
   workup.DISSOLUTIONThe precipitate was then dissolved in ethyl acetate
5. 5
   萃取extracted with sodium bicarbonate solution
6. 6
   洗涤After washing
7. 7
   其他drying
8. 8
   其他the product was obtained

实验过程

56 g of N-(2-methyl-3-methoxycarbonylphenyl)thiourea (0.25 mol) were dissolved in 2 l of chlorobenzene, and the mixture was cooled to 0° C. 40 g of bromine (0.25 mol) in 100 ml of chlorobenzene were then added dropwise. The reaction mixture was heated at 90° C. for 3 h, and the precipitate was filtered off with suction and washed with methylene chloride. The precipitate was then dissolved in ethyl acetate and extracted with sodium bicarbonate solution. After washing and drying, the product was obtained by stripping off the solvent. Yield: 43 g (80%).

来源