反应 #1350588

反应方程式

15-crown-5

sulfuric acid

methyl 3-amino-2-methylbenzoate

sodium thiocyanate

→

N-(2-Methyl-3-methoxycarbonylphenyl)thiourea

溶剂

chlorobenzene

反应条件

后处理

1. 1
   温度After cooling
2. 2
   过滤the solid was filtered off with.suction,
3. 3
   洗涤washed with water
4. 4
   其他dried

实验过程

90.7 g of methyl 3-amino-2-methylbenzoate (0.55 mol) were dissolved in 510 ml of chlorobenzene and, at −5° C., admixed with 14 ml of conc. sulfuric acid and 49 g of sodium thiocyanate (0.6 mol). 2 ml of 15-crown-5 were then added, and the reaction mixture was heated at 100° C. for 13 h. After cooling, the solid was filtered off with.suction, washed with water and dried. Yield: 104.8 g (85%).

来源