反应 #1350581

反应方程式

3-methyl-2,4-dicyanothiophenol

NaOH

dimethyl sulfate

→

3-Methyl-2,4-dicyanothioanisole

溶剂

water

反应条件

后处理

1. 1
   workup.ADDITIONwere then added dropwise at 25-35° C
2. 2
   其他after which a solid had precipitated out
3. 3
   过滤which was filtered off with suction
4. 4
   洗涤washed twice with water
5. 5
   其他recrystallized from glacial acetic acid/water

实验过程

50 g (0.29 mol) of 3-methyl-2,4-dicyanothiophenol were added to a solution of 23 g (0.58 mol) of NaOH in 400 ml of water, and 73 g (0.58 mol) of dimethyl sulfate were then added dropwise at 25-35° C. The mixture was stirred at 25° C. for 16 h, after which a solid had precipitated out, which was filtered off with suction, washed twice with water and then recrystallized from glacial acetic acid/water. Yield: 43 g (80%).

来源