反应 #1350563

反应方程式

pyrrolidine

cyclooctanone

magnesium sulfate

→

desired product

N-cyclooctylpyrrolidine

溶剂

hexane

反应条件

后处理

1. 1
   workup.ADDITIONflask was charged with 75 gm
2. 2
   温度heated
3. 3
   温度at reflux (the reaction
4. 4
   其他for 108 hours
5. 5
   过滤The reaction mixture was filtered through a fritted glass funnel
6. 6
   浓缩The filtrate was concentrated at reduced pressure on a rotary evaporator
7. 7
   其他to give 70.5 gm

实验过程

A three-neck 3000 ml. flask was charged with 75 gm. (1.05 moles) of pyrrolidine, 51 gm. cyclooctanone (0.4 mole) and 80 ml. anhydrous hexane. To the resulting solution, 80 gm. (0.8 mole) of anhydrous magnesium sulfate was added and the mixture was mechanically stirred and heated at reflux (the reaction was monitored by NMR analysis) for 108 hours. The reaction mixture was filtered through a fritted glass funnel. The filtrate was concentrated at reduced pressure on a rotary evaporator to give 70.5 gm. of a clear (yellow-tinted) oily substance. 1H-NMR and 13C-NMR spectra were acceptable for the desired product, 1-(1-pyrrolino)cyclooctene. Saturation of the 1-(1-pyrrolino)cyclooctene to give N-cyclooctylpyrrolidine was accomplished in 98% yield by catalytic hydrogenation in ethanol at a 55 psi pressure of hydrogen gas in the presence of 10% Pd on activated carbon.

来源