反应 #1350562

反应方程式

2-amino-2,2-dimethylethanol

acetone

2-amino-2,2-dimethylethanol

→

colorless liquid

收率 77.5%

2,2,4,4-Tetramethyl-1,3-oxazolidine

收率 77.5%

溶剂

methylene chloride

反应条件

后处理

1. 1
   温度The reaction mixture is heated
2. 2
   浓缩than concentrated under vacuum (200 mm Hg/30° C.)

实验过程

Into a 500 mL, three-necked flask with a reverse Dean-Stark trap is added 45 g (500 mmol) of 2-amino-2,2-dimethylethanol, 40 g (700 mmol) of acetone and 200 mL of methylene chloride. The reaction mixture is heated to reflux for 16 hours until no starting 2-amino-2,2-dimethylethanol is detected. The reaction mixture is allowed to cool to ambient temperature and is than concentrated under vacuum (200 mm Hg/30° C.) to give 50 g (77.5% yield) of a colorless liquid. The product is identified by mass spectroscopy (m/z=129) and 1Hnmr analysis.

来源