反应 #1345023

反应方程式

Methyl chloroformate

1-(4-bromo-2-fluorophenyl)methanamine

triethylamine

→

methyl(4-bromo-2-fluorobenzyl)carbamate

溶剂

methylene chloride

反应条件

后处理

1. 1
   其他the ice-water bath was removed
2. 2
   洗涤washed with water, and brine
3. 3
   干燥The organic layer was dried over Na2SO4
4. 4
   过滤filtered
5. 5
   浓缩concentrated under reduced pressure
6. 6
   其他The residue (220 mg, 83.9%) was directly used in next step without further purification

实验过程

Methyl chloroformate (85.0 μL, 1.1 mmol) was added to a solution of 1-(4-bromo-2-fluorophenyl)methanamine (0.204 g, 1.0 mmol) and triethylamine (148.1 μL, 1.1 mmol) in methylene chloride (5 mL) at 0° C. After 10 min, the ice-water bath was removed. The mixture was stirred at RT for 1 h, washed with water, and brine. The organic layer was dried over Na2SO4, filtered, and concentrated under reduced pressure. The residue (220 mg, 83.9%) was directly used in next step without further purification. LCMS: (M+H)=263.9/261.8.

来源