反应 #1340619

反应方程式

4-aminobenzoic acid

cyclohexanecarbonyl chloride

Et3N

NaOH

methyl 4-(cyclohexanecarboxamido)benzoate

→

48d

收率 92.0%

4-(Cyclohexanecarboxamido)benzoic acid

收率 92.0%

溶剂

THF

反应条件

后处理

1. 1
   workup.STIRRINGthe reaction mixture was stirred for 5 h at room temperature
2. 2
   其他The THF was removed by rotary evaporation and 1N aqueous HCl
3. 3
   workup.ADDITIONwas added
4. 4
   其他to precipitate the product, which
5. 5
   过滤was filtered

实验过程

A mixture of 4-aminobenzoic acid 48a (1.98 mmol, 300 mg), cyclohexanecarbonyl chloride 48b (1.98 mmol, 291 mg), and Et3N (2.52 mmol, 0.43 mL) in 6 mL of THF was stirred at room temperature overnight. 1N aqueous NaOH (7.9 mmol, 7.9 mL) was added to the mixture (containing methyl 4-(cyclohexanecarboxamido)benzoate 48c) and the reaction mixture was stirred for 5 h at room temperature. The THF was removed by rotary evaporation and 1N aqueous HCl was added to precipitate the product, which was filtered to give 480 mg (92%) of 48d.

来源