反应 #1340618

反应方程式

4-formylbenzoic acid

2-fluoroaniline

decaborane

→

47c

收率 99.2%

4-(((2-fluorophenyl)amino)methyl)benzoic acid

收率 99.2%

溶剂

MeOH

反应条件

后处理

1. 1
   浓缩The mixture was concentrated
2. 2
   其他purified by preparative reverse-phase chromatography

实验过程

A mixture of 4-formylbenzoic acid 47a (3.33 mmol, 500 mg), 2-fluoroaniline 47b (3.33 mmol, 370 mg), and decaborane (1 mmol, 122 mg) in 8 mL of MeOH was stirred at room temperature for 15 min. The mixture was concentrated and purified by preparative reverse-phase chromatography to afford 0.81 g (99%) of 47c.

来源