反应 #1340617

反应方程式

methyl 2-phenyl-benzooxazole-6-carboxylate

LiOH

2-Phenyl-benzooxazole-6-carboxylic acid

HCl

→

1t

benzoyl chloride

溶剂

THF

MeOH

H2O

反应条件

后处理

1. 1
   萃取The resulting mixture was extracted with EtOAc (2×)
2. 2
   洗涤The organic solution was washed with aq. NaCl
3. 3
   干燥dried over Na2SO4
4. 4
   浓缩concentrated

实验过程

2-Phenyl-benzooxazole-6-carboxylic acid, 1v. A mixture of methyl 2-phenyl-benzooxazole-6-carboxylate 1u (0.37 g, 1.46 mmol) and LiOH (0.10 g, 4.2 mmol) in THF (4 mL), MeOH (4 mL), and H2O (4 mL) was stirred at room temperature for 6 h. Aqueous 1N HCl solution was added to the mixture to adjust pH to 3-4. The resulting mixture was extracted with EtOAc (2×). The organic solution was washed with aq. NaCl, dried over Na2SO4 and concentrated to give 1t (0.34 g).

来源