反应 #1340611

反应方程式

hydrogen

(3S)-1-benzyloxycarbonyl-3-(tert-butoxycarbonyl)amino-4-vinylpyrrolidine

→

title compound

(3S)-3-(tert-Butoxycarbonyl)amino-4-ethylpyrrolidine

溶剂

ethanol

反应条件

后处理

1. 1
   过滤After filtration
2. 2
   浓缩the filtrate was concentrated under reduced pressure

实验过程

A 10% palladium carbon catalyst (15 mg) was added to a solution of (3S)-1-benzyloxycarbonyl-3-(tert-butoxycarbonyl)amino-4-vinylpyrrolidine [an isomer mixture of (4S)-form:(4R)-form (1:4)] (230 mg, 0.66 mmol) in ethanol (8 mL), followed by stirring in a hydrogen atmosphere under an ordinary pressure at room temperature for 12 hours. After filtration, the filtrate was concentrated under reduced pressure, to thereby yield the title compound (an isomer mixture of (4S)-form and (4R)-form (1:4)) as a colorless oily substance (148 mg, 100%).

来源