反应 #1328424

反应方程式

methyl 2-hydroxy-4-methoxybenzoate

dichloromethoxymethane

→

methyl 2-hydroxy-3-formyl-4-methoxybenzoate

收率 42.4%

溶剂

methylene chloride

methylene chloride

反应条件

后处理

1. 1
   萃取extracted with methylene chloride
2. 2
   洗涤The combined organic phases were washed with sodium bicarbonate solution, water and sodium chloride solution
3. 3
   其他dried
4. 4
   其他the solvent was then removed

实验过程

At from 0 to 5° C., a solution of 209.0 g (1.1 mol) of titanium tetrachloride in 150 ml of methylene chloride was added dropwise to a solution of 50.1 g (0.275 mol) of methyl 2-hydroxy-4-methoxybenzoate and 88 g (0.725 mol) of dichloromethoxymethane in 400 ml of methylene chloride, and the mixture was stirred at room temperature overnight. The mixture was then stirred into ice-water and extracted with methylene chloride. The combined organic phases were washed with sodium bicarbonate solution, water and sodium chloride solution and dried, and the solvent was then removed. Silica gel chromatography using cyclohexane/ethyl acetate=1:1 gave 24.5 g (42%) of methyl 2-hydroxy-3-formyl-4-methoxybenzoate in the form of a colorless solid of m.p.: 123–1240° C.

来源