反应 #1328423

反应方程式

methyl 5-chloro-4-oxothiochromane-8-carboxylate

N,N-dimethylformamide dimethyl acetal

→

methyl 5-chloro-3-(N,N-dimethylaminomethylidene)-4-oxothiochromane-8-carboxylate

收率 97.0%

反应条件

后处理

1. 1
   workup.DISTILLATIONVolatile components were then distilled off
2. 2
   洗涤the organic phase was washed with water
3. 3
   其他Drying
4. 4
   其他removal of the solvent

实验过程

30 g (0.078 mol) of methyl 5-chloro-4-oxothiochromane-8-carboxylate in 300 ml of N,N-dimethylformamide dimethyl acetal were refluxed for 6 hours. Volatile components were then distilled off, the residue was taken up in methylene chloride and the organic phase was washed with water. Drying and removal of the solvent gave 35.3 g (97%) of methyl 5-chloro-3-(N,N-dimethylaminomethylidene)-4-oxothiochromane-8-carboxylate.

来源