反应 #1328417

反应方程式

sodium hypochlorite

2-allyl-6-chlorobenzaldehyde oxime

sodium acetate

→

8-Chloro-3a,4-dihydro-3H-indeno[1,2-c]isoxazole

溶剂

methylene chloride

反应条件

后处理

1. 1
   其他the organic phase was separated off
2. 2
   萃取the aqueous phase was extracted with methylene chloride
3. 3
   洗涤the combined organic phases were washed with saturated ammonium chloride solution
4. 4
   其他The organic phase was dried
5. 5
   其他the solvent was removed

实验过程

At room temperature, 37.0 ml of a sodium hypochlorite solution (12.5% of active chlorine) were added dropwise to a solution of 8.4 g (42.9 mmol) of 2-allyl-6-chlorobenzaldehyde oxime in 100 ml of methylene chloride, and a spatula tip of sodium acetate was added. The mixture was stirred at room temperature for 2 hours, the organic phase was separated off, the aqueous phase was extracted with methylene chloride and the combined organic phases were washed with saturated ammonium chloride solution. The organic phase was dried and the solvent was removed. This gave 7.0 g (94%) of 8-chloro-3a,4-dihydro-3H-indeno-[1,2-c]isoxazole in the form of a viscous oil.

来源