反应 #1328416

反应方程式

2-allyl-6-chlorobenzaldehyde

sodium bicarbonate

hydroxylamine hydrochloride

→

2-Allyl-6-chlorobenzaldehyde oxime

溶剂

methanol

water

反应条件

后处理

1. 1
   其他The methanol was subsequently removed under reduced pressure
2. 2
   workup.STIRRINGthe residue was stirred into 300 ml of water
3. 3
   萃取The aqueous phase was extracted with diethyl ether
4. 4
   洗涤the combined organic phases were washed with saturated ammonium chloride solution
5. 5
   其他dried
6. 6
   其他the solvent was removed

实验过程

5.58 g of sodium bicarbonate were added to a solution of 4.62 g of hydroxylamine hydrochloride in 50 ml of water, and the mixture was cooled to 0° C. A solution of 9.7 g (44.32 mmol) of 2-allyl-6-chlorobenzaldehyde in 50 ml of methanol was then added dropwise, and the mixture was stirred at room temperature overnight. The methanol was subsequently removed under reduced pressure and the residue was stirred into 300 ml of water. The aqueous phase was extracted with diethyl ether and the combined organic phases were washed with saturated ammonium chloride solution and dried, and the solvent was removed. This gave 8.7 g (quantitative) of 2-allyl-6-chlorobenzaldehyde oxime in the form of a viscous oil.

来源