反应 #1328412

反应方程式

(R)-7-Benzyloxy-3-(2-phthalimidopropyl)indole

water

Ammonium formate

→

(R)-7-hydroxy-3-(2-phthalimidopropyl)indole

溶剂

ethanol

反应条件

后处理

1. 1
   其他prepared separately
2. 2
   workup.ADDITIONwas added
3. 3
   温度After cooling down
4. 4
   过滤the catalyst was filtered off
5. 5
   浓缩the filtrate was concentrated under reduced pressure
6. 6
   workup.ADDITIONAcetone was added to the residue
7. 7
   过滤a deposited salt was filtered off
8. 8
   浓缩The filtrate was concentrated under reduced pressure, whereby 10.27 g of a residue
9. 9
   workup.ADDITIONcontaining the title compound
10. 10
    其他was obtained

实验过程

(R)-7-Benzyloxy-3-(2-phthalimidopropyl)indole 12.16 g was dissolved in 400 ml of ethanol, and a water 100 ml suspension of a 10% palladium on carbon catalyst (content 50%) 4.00 g prepared separately was added thereto. Ammonium formate 6.00 g was added thereto while stirring, and the suspension was heated in an oil bath of 95° C. For one hour. After cooling down, the catalyst was filtered off, and the filtrate was concentrated under reduced pressure. Acetone was added to the residue, and a deposited salt was filtered off. The filtrate was concentrated under reduced pressure, whereby 10.27 g of a residue containing the title compound was obtained.

来源