反应 #1328411

反应方程式

(S)-7-benzyloxy-3-(3-iodo-2-phthalimidopropyl)indole

potassium carbonate

ammonium formate

→

title compound

收率 79.4%

(R)-7-benzyloxy-3-(2-phthalimidopropyl)indole

收率 79.4%

溶剂

DMF

反应条件

后处理

1. 1
   workup.ADDITIONAdded
2. 2
   温度After cooling down
3. 3
   过滤the catalyst was filtered off
4. 4
   workup.ADDITIONthe filtrate was diluted with ethyl acetate
5. 5
   workup.ADDITIONThen, water was added
6. 6
   其他the organic layer was separated
7. 7
   洗涤The organic layer was washed in order with a 10% sodium thiosulfate aqueous solution
8. 8
   干燥a sodium hydroxide aqueous solution, hydrochloric acid and a saturated sodium chloride aqueous solution, and then it was dried
9. 9
   过滤filtered
10. 10
    浓缩concentrated under reduced pressure

实验过程

A 10% palladium on carbon catalyst (content 50%) 4.00 g was suspended in 200 ml of DMF, and 20.00 g of (S)-7-benzyloxy-3-(3-iodo-2-phthalimidopropyl)indole was added thereto. Added while stirring were 8.00 g of potassium carbonate and 6.00 g of ammonium formate, the suspension was heated in an oil bath of 85° C. For one hour. After cooling down, the catalyst was filtered off, and the filtrate was diluted with ethyl acetate. Then, water was added thereto, and the organic layer was separated. The organic layer was washed in order with a 10% sodium thiosulfate aqueous solution, a sodium hydroxide aqueous solution, hydrochloric acid and a saturated sodium chloride aqueous solution, and then it was dried, filtered and concentrated under reduced pressure, whereby 12.16 g of the title compound was obtained in the form of a yellow amorphous solid shaped substance.

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