反应 #1328400

反应方程式

N-BOC-N,N-bis-(N′,N′-bis(5-methoxycarbonylpentyl)-5-carbamyl pentyl)-amine

N-BOC-N,N-Bis-(N′,N′-Bis(5-Methoxycarbonylpentyl)-5-Carbamyl pentyl)Amine

trifluoroacetic acid

→

N,N-Bis-(N′,N′-Bis(5-Methoxycarbonylpentyl)-5-carbamyl pentyl)-Amine TFA

溶剂

methylene chloride

反应条件

后处理

1. 1
   浓缩concentrated
2. 2
   workup.ADDITIONThe residue was diluted with 50 mL of methylene chloride
3. 3
   浓缩concentrated via rotary evaporation
4. 4
   workup.ADDITIONThe residue was then diluted with 50 mL of methanol
5. 5
   浓缩re-concentrated via rotary evaporation
6. 6
   workup.ADDITIONThe residue was again re-diluted with 50 mL of methylene chloride
7. 7
   浓缩re-concentrated, first via rotary evaporation

实验过程

To a 250 mL round bottom flask, charged with 1.50 g (1.75 mmol) of N-BOC-N,N-bis-(N′,N′-bis(5-methoxycarbonylpentyl)-5-carbamyl pentyl)-amine (17) in 15 mL of methylene chloride, was added 15 mL of trifluoroacetic acid. The mixture was stirred at room temperature for 15 minutes and then concentrated. The residue was diluted with 50 mL of methylene chloride and then concentrated via rotary evaporation. The residue was then diluted with 50 mL of methanol and re-concentrated via rotary evaporation. The residue was again re-diluted with 50 mL of methylene chloride and re-concentrated, first via rotary evaporation and then under full vacuum pump pressure (<0.5 mm Hg).

来源