反应 #1328395

反应方程式

6-bromohexanoic acid

methanol

→

product

收率 99.0%

Methyl 6-bromohexanoate

收率 99.0%

反应条件

后处理

1. 1
   其他was bubbled hydrogen chloride gas for 2–3 minutes
2. 2
   浓缩concentrated

实验过程

To a 1 L round bottom flask, charged with 20 g (102.5 mmol) of 6-bromohexanoic acid and 500 mL of methanol, was bubbled hydrogen chloride gas for 2–3 minutes. The mixture was stirred at room temperature for 4 hours and concentrated to afford 21.0 g of the product as a yellow oil (99%): 1H-NMR (200 MHz, d6-DMSO); 3.57 (s, 3H), 3.51 (t, 2H), 2.30 (t, 2H), 1.78 (pentet, 2H), and 1.62–1.27 (m, 4H) ppm.

来源